Browsing by Author "Hetz Flores, Claudio"

Now showing items 1-20 of 119

    • A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway 
      Zamorano, Sebastián; Rojas Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero González, Sergio; Hetz Flores, Claudio (2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
    • A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease 
      Gerakis, Yannis; Hetz Flores, Claudio (Elsevier, 2018)
      Alterations in the buffering capacity of the proteostasis network are a salient feature of Alzheimer's disease, associated with the occurrence of chronic endoplasmic reticulum (ER) stress. To cope with ER stress, cells ...
    • A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice 
      Acuña, Aníbal I.; Esparza, Magdalena; Kramm, Carlos; Beltrán, Felipe A.; Parra, Alejandra V.; Cepeda, Carlos; Toro, Carlos A.; Vidal, René L.; Hetz Flores, Claudio; Concha, Ilona I.; Brauchi, Sebastián; Levine, Michael S.; Castro, Maite A. (Nature Publishing Group, 2013)
      Huntington's disease has been associated with a failure in energy metabolism and oxidative damage. Ascorbic acid is a powerful antioxidant highly concentrated in the brain where it acts as a messenger, modulating neuronal ...
    • A new method to measure autophagy flux in the nervous system 
      Matus, Soledad; Valenzuela, Vicente; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      A current need in the neuroscience field is a simple method to monitor autophagic activity in vivo in neurons. Until very recently, most reports have been based on correlative and static determinations of the expression ...
    • A new model to study cell-to-cell transfer of αSynuclein in vivo 
      Mercado, Gabriela; López, Nélida; Martínez, Alexis; Sardi, Sergio P.; Hetz Flores, Claudio (Elsevier B.V., 2018)
      © 2018 Elsevier Inc. Parkinson's disease (PD) compromises motor control due to the loss of dopaminergic neurons in the substantia nigra pars compacta. At the histopathological level, PD is characterized by the accumulation ...
    • A Novel ER Stress-Independent Function of the UPR in Angiogenesis 
      Urra, Hery; Hetz Flores, Claudio (Cell Press, 2014)
      Tumors rely on the unfolded protein response (UPR) and angiogenesis to survive the metabolic stress of hypoxia. Karali et al. (2014) revealed that VEGF signaling engages UPR sensors in an unconventional manner that is ...
    • AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation ... 
      Zuleta, Amparo; Vidal, Rene L.; Armentano, Donna; Parsons, Geoffrey; Hetz Flores, Claudio (2012)
      Huntington's disease (HD) is caused by mutations that expand a polyglutamine region in the amino-terminal domain of Huntingtin (Htt), leading to the accumulation of intracellular inclusions and progressive neurodegeneration. ...
    • Acute pannexin 1 blockade mitigates early synaptic plasticity defects in a mouse model of Alzheimer's disease 
      Flores Muñoz, Carolina; Gómez, Bárbara; Mery, Elena; Mujica, Paula; Gajardo, Ivana; Córdova, Claudio; López Espíndola, Daniela; Durán Aniotz, Claudia; Hetz Flores, Claudio; Muñoz, Pablo; González Jamett, Arlek; Ardiles, Álvaro (Frontiers Media, 2020)
      Synaptic loss induced by soluble oligomeric forms of the amyloid beta peptide (sA beta os) is one of the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the cognitive deficits. These ...
    • Addicted to secrete - novel concepts and targets in cancer therapy 
      Dejeans, Nicolas; Manié, Serge; Hetz Flores, Claudio; Bard, Frédéric; Hupp, Ted; Agostinis, Patrizia; Samali, Afshin; Chevet, Eric (Elsevier Ltd, 2014)
      The unfolded protein response (UPR) mediates the adaptation of the secretory pathway (SP) to fluctuations in cellular protein demand or to environmental variations. Recently, drug screenings have confirmed the therapeutic ...
    • ALS-linked protein disulfide isomerase variants cause motor dysfunction 
      Woehlbier, Ute; Colombo Flores, Alicia; Saaranen, Mirva J.; Pérez, Viviana; Ojeda, Jorge; Bustos, Fernando J.; Andreu, Catherine; Torres, Mauricio; Valenzuela, Vicente; Medinas Bilches, Danilo; Rozas, Pablo; Vidal, René L.; López González, Rodrigo; Salameh, Johnny; Fernández Collemann, Sara; Muñoz, Natalia; Matus, Soledad; Armisen Yáñez, Ricardo; Sagredo, Alfredo; Palma, Karina; Irrázabal, Thergiory; Almeida, Sandra; González Pérez, Paloma; Campero, Mario; Gao, Fen-Biao; Henny, Pablo; Van Zundert, Brigitte; Ruddock, Lloyd W.; Concha, Miguel L.; Henríquez, Juan P.; Brown, Robert H.; Hetz Flores, Claudio (Wiley-Blackwell, 2016)
      Disturbance of endoplasmic reticulum (ER) proteostasis is a common feature of amyotrophic lateral sclerosis (ALS). Protein disulfide isomerases (PDIs) are ER foldases identified as possible ALS biomarkers, as well as ...
    • Altered prion protein expression pattern in CSF as a biomarker for creutzfeldt-jakob disease 
      Torres, Mauricio; Cartier Rovirosa, Luis; Matamala, José Manuel; Hernández, Nancy; Woehlbier, Ute; Hetz Flores, Claudio (2012)
      Creutzfeldt-Jakob disease (CJD) is the most frequent human Prion-related disorder (PrD). The detection of 14-3-3 protein in the cerebrospinal fluid (CSF) is used as a molecular diagnostic criterion for patients clinically ...
    • Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in ... 
      Paula Lima, Andrea; Adasme, Tatiana; San Martín Rovirosa, Carol; Sebollela, Adriano; Hetz Flores, Claudio; Carrasco, M. Angélica; Ferreira, Sergio T.; Hidalgo Tapia, María Cecilia (2011)
      Soluble amyloid β-peptide oligomers (AβOs), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca2+ homeostasis and synaptic function. Here, we report that AβOs at sublethal concentrations ...
    • Amyotrophic lateral sclerosis pathogenesis: A journey through the secretory pathway 
      Nassif, Melissa; Matus, Soledad; Castillo, Karen; Hetz Flores, Claudio (2010)
      Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motoneuron degenerative disease characterized by the selective loss of motoneurons in the spinal ventral horn, most brainstem nuclei, and the cerebral ...
    • An ERcentric view of Parkinson's disease 
      Mercado, Gabriela; Valdés, Pamela; Hetz Flores, Claudio (2013)
      Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta and the accumulation of intracellular ...
    • Apoptosis, necrosis and autophagy: From mechanisms to biomedical applications 
      Hetz Flores, Claudio (2008)
    • Astrocytic α vβ 3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by ... 
      Herrera Molina, Rodrigo; Frischknecht, Renato; Maldonado, Horacio; Seidenbecher, Constanze I.; Gundelfinger, Eckart D.; Hetz Flores, Claudio; Aylwin Ostale, María de la Luz; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (2012)
      Thy-1 is a membrane glycoprotein suggested to stabilize or inhibit growth of neuronal processes. However, its precise function has remained obscure, because its endogenous ligand is unknown. We previously showed that Thy-1 ...
    • Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor ... 
      González, Alexis E.; Muñoz, Vanessa C.; Cavieres, Viviana A.; Bustamante, Hianara A.; Cornejo, Víctor Hugo; Januário, Yunan C.; González, Ibeth; Hetz Flores, Claudio; Dasilva, Luis L.; Rojas-Fernández, Alejandro; Hay, Ronald T.; Mardones, Gonzalo A.; Burgos, Patricia V. (FASEB, 2017)
      © FASEB. Brain regions affected by Alzheimer disease (AD) displaywell-recognized early neuropathologic features in the endolysosomal and autophagy systems of neurons, including enlargement of endosomal compartments, ...
    • Autophagy impairment: A crossroad between neurodegeneration and tauopathies 
      Nassif, Melissa; Hetz Flores, Claudio (2012)
      Most neurodegenerative diseases involve the accumulation of misfolded proteins in the nervous system. Impairment of protein degradation pathways such as autophagy is emerging as a consistent and transversal pathological ...
    • Autophagy in hepatic adaptation to stress 
      Hazari, Younis M.; Bravo San Pedro, José Manuel; Hetz Flores, Claudio; Galluzzi, Lorenzo; Kroemer, Guido (Elsevier, 2020)
      Autophagy is an evolutionarily ancient process whereby eukaryotic cells eliminate disposable or potentially dangerous cytoplasmic material, to support bioenergetic metabolism and adapt to stress. Accumulating evidence ...
    • BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α 
      Lisbona, Fernanda; Rojas Rivera, Diego; Thielen, Peter; Zamorano, Sebastian; Todd, Derrick; Martinon, Fabio; Glavic Maurer, Álvaro; Kress, Christina; Lin, Jonathan H.; Walter, Peter; Reed, John C.; Glimcher, Laurie H.; Hetz Flores, Claudio (2009)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (BI-1) is an evolutionarily conserved ...